My laboratory focuses on understanding the structure-function relationship of nucleic acid molecules, and based on these knowledges, develops diagnostic and therapeutic tools against various diseases.
Nucleic acid aptamers are short, single stranded oligonucleotides which can fold into specific three dimentional structure to bind target molecules with high affinity and specificity. My lab is focusing on generating aptamers targeting cancer cell surface marker proteins, such as pancreatic cancer cells, and trying to use this aptamer for cancer diagnostics and therapeutics. RNA interference is an endogenous gene silencing mechanism which allows short double stranded RNA (siRNA) to specifically target gene of interest and inhibit its expression. My lab has developed a variety of novel RNAi triggering molecular platforms which shows improved features over the original siRNA structures. We continue to develop next generation RNAi technologies and try to use these technologies to develop therapeutics against a variety of diseases.
Journal Articles
(2022)
Nonbiodegradable Spiegelmer-Driven Colorimetric Biosensor for Bisphenol A Detection.
BIOSENSORS-BASEL.
12,
10
(2022)
Retinoic Acid-Inducible Gene I-Mediated Innate Immune Stimulation by Chemically Synthesized Long Double-Stranded RNAs Is Structure and Sequence Dependent.
NUCLEIC ACID THERAPEUTICS.
32,
4
(2020)
L-Type Calcium Channel Blocker Enhances Cellular Delivery and Gene Silencing Potency of Cell-Penetrating Asymmetric siRNAs.
MOLECULAR PHARMACEUTICS.
17,
3
(2019)
ALPPL2 Is a Potential Diagnostic Biomarker for Pancreatic Cancer-Derived Extracellular Vesicles.
MOLECULAR THERAPY-METHODS CLINICAL DEVELOPMENT.
15,
-
(2019)
Detection of Gram-negative bacterial outer membrane vesicles using DNA aptamers.
SCIENTIFIC REPORTS.
9,
-
(2018)
Multi-block magnetic nanorods for controlled drug release modulated by Fourier transform surface plasmon resonance.
NANOSCALE.
10,
39
(2018)
Multi-block magnetic nanorods for controlled drug release modulated by Fourier transform surface plasmon resonance..
NANOSCALE.
10,
39
(2018)
Cell-SELEX based identification of a human and mouse cross-reactive endothelial cell-internalizing aptamer..
NUCLEIC ACID THERAPEUTICS.
28,
4
(2018)
Cell-SELEX-Based Identification of a Human and Mouse Cross-Reactive Endothelial Cell-Internalizing Aptamer.
NUCLEIC ACID THERAPEUTICS.
28,
4
(2018)
Construction of histidine-containing hydrocarbon stapled cell penetrating peptides for in vitro and in vivo delivery of siRNAs.
CHEMICAL SCIENCE.
9,
15
(2018)
Construction of histidine-containing hydrocarbon stapled cell penetrating peptides for in vitro and in vivo delivery of siRNAs..
CHEMICAL SCIENCE.
9,
15
(2018)
RNA interference-mediated gene silencing by branched tripodal RNAs does not require Dicer processing..
NUCLEIC ACID THERAPEUTICS.
28,
1
(2018)
RNA Interference-Mediated Gene Silencing by Branched Tripodal RNAs Does Not Require Dicer Processing.
NUCLEIC ACID THERAPEUTICS.
28,
1
(2016)
Cell-SELEX Based Identification of an RNA Aptamer for Escherichia coli and Its Use in Various Detection Formats.
MOLECULES AND CELLS.
39,
11
(2016)
Development of Cell-Penetrating Asymmetric Interfering RNA Targeting Connective Tissue Growth Factor.
JOURNAL OF INVESTIGATIVE DERMATOLOGY.
136,
11
(2015)
Phosphonium Polymethacrylates for Short Interfering RNA Delivery: Effect of Polymer and RNA Structural Parameters on Polyplex Assembly and Gene Knockdown.
BIOMACROMOLECULES.
16,
11
(2015)
Understanding the molecular aspects of oriental obesity pattern differentiation using DNA microarray.
JOURNAL OF TRANSLATIONAL MEDICINE.
13,
1
(2015)
ALPPL2 Aptamer-Mediated Targeted Delivery of 5-Fluoro-2 '-Deoxyuridine to Pancreatic Cancer.
NUCLEIC ACID THERAPEUTICS.
25,
4
Patent/Intellectual Property
신규 DNA-RNA 하이브리드 정사면체 구조물 또는 RNA 정사면체 구조물.
10-2015-0029242.
20171127.
KOREA, REPUBLIC OF
ＨＥＲ－２ 과발현 유방암 세포 또는 조직에 특이적으로 결합할 수 있는 핵산 압타머 및 그 용도.
10-2010-0006163.
20170712.
KOREA, REPUBLIC OF
RNA 간섭을 유도하는 핵산 분자 및 그 용도.
PCT/KR2011/006632.
20170502.
UNITED STATES
ALPPL2 단백질을 이용한 췌장암 진단 방법.
10-2012-0033932.
20170117.
KOREA, REPUBLIC OF
ALPPL2 단백질을 이용한 췌장암 진단 방법.
10-2012-0033932.
20161025.
KOREA, REPUBLIC OF
목적 유전자의 발현 억제 특이성이 증가된 siRNA 분자.
10-2014-0086224.
20161024.
KOREA, REPUBLIC OF
안티센스 가닥에 의한 오프-타겟 효과를 최소화한 신규한 ｓｉＲＮＡ 구조 및 그 용도.
10-2010-0109403.
20160216.
UNITED STATES
긴 안티센스 가닥을 가지는 작은 간섭 알엔에이.
10-2010-0103701.
20150821.
JAPAN
췌장암 세포 또는 조직에 특이적으로 결합할 수 있는 핵산 압타머 및 그 용도.
10-2010-0051761.
20140829.
JAPAN
세포 내 전달능이 증가된 작은 간섭 RNA 복합체.
PCT/KR2010/000678.
20140425.
JAPAN
RNA 압타머를 이용한 췌장암 진단 및 치료.
PCT/KR2010/003536.
20131211.
UNITED STATES
RNA 간섭을 유도하는 핵산분자 및 그 용도.
10-2010-0103701.
20131106.
KOREA, REPUBLIC OF
췌장암 세포 또는 조직에 특이적으로 결합할 수 있는 핵산압타머 및 그 용도.
10-2009-0047940.
20121004.
KOREA, REPUBLIC OF
세포 내 전달능이 증가된 작은 간섭 RNA 복합체.
10-2010-0010420.
20120723.
KOREA, REPUBLIC OF
Conference Paper
(2021)
RIG-I-Mediated Innate Immune Stimulation By Chemically Synthesized Long Double-Stranded RNAs Is Structure- And Sequence-Dependent.
128th General Meeting of the Korean Chemical Society.
KOREA, REPUBLIC OF
(2021)
Therapeutic development using chemically modified asymmetric small interfering RNAs.
128th General Meeting of the Korean Chemical Society.
KOREA, REPUBLIC OF
(2021)
RIG-I-Mediated Innate Immune Stimulation By Chemically Synthesized Long Double-Stranded RNAs Is Structure- And Sequence-Dependent.
2021 Oligonucleotide Therapeutics Society.
UNITED STATES
(2020)
Therapeutic development using asymmetric siRNAs.
제15회 KSGCT 정기학술대회.
KOREA, REPUBLIC OF
(2020)
Development of first in class therapeutics for age related macular degeneration using cell penetrating asymmetric siRNA technology.
OTS meeting 2020.
UNITED STATES
(2020)
Therapeutic development using chemically modified asymmetric small interfering RNAs.
제125회 대한화학회 학술발표회 및 총회.
KOREA, REPUBLIC OF
(2019)
그람 음성 박테리아 스크리닝을 위한 outer membrane vesicle 검출 DNA aptasensor.
한국화생방방어학회 2019 학술대회.
KOREA, REPUBLIC OF
(2019)
Aptamer bead-mediated separation of gram-negative bacteria using microfluidic acoustophoresis.
대한화학회 2020 추계학술대회.
KOREA, REPUBLIC OF
(2019)
Detection of Gram-negative bacterial outermembrane vehicles using DNA aptamers.
대한화학회 2020년 추계학술대회.
KOREA, REPUBLIC OF
(2018)
Functional Nucleic Acid Tetrahedron-mediated Gene Silencing Effect.
14th annual meeting of the oligonucleotide therapeutics society.
UNITED STATES
(2018)
병원성 그람 음성 박테리아에 범용적으로 결합할 수 있는 DNA 압타머 개발 및 응용.
2018 한국군사과학기술학회.
KOREA, REPUBLIC OF
(2018)
Chemically Synthesized Long dsRNAs are a Potent RNAi Therapeutic Platform Circumventing Innate Immune Response.
RNA 2018.
UNITED STATES
(2017)
Alkaline phosphatase placental like 2 as a diagnostic biomarker for detection of pancreatic ductal adenocarcinoma.
The 13th Annual Meeting of the Oligonucleotide Therapeutics Society.
FRANCE
(2017)
보툴리늄 신경독소 E에 대한 DNA 압타머 선별 및 형광 압타머 센서 제작.
2017 한국군사과학기술학회 종합학술대회.
KOREA, REPUBLIC OF
(2017)
Characterization of innate immune stimulation induced by various RNA structures.
RNA and Oligonucleotide Therapeutics.
UNITED STATES
(2017)
Gene silencing mediated by functional nucleic acid tetrahedron.
RNA and Oligonucleotide Therapeutics.
UNITED STATES
(2016)
Cell-SELEX based identification of an RNA aptamer for Escherichia coli and its use in various detection formats.
2016 annual fall meeting of the korean biochip society.
KOREA, REPUBLIC OF
(2016)
Development of an aptamer-based fluorometric detection of Botulinum neurotoxin E.
2016 annual fall meeting of the korean biochip society.
KOREA, REPUBLIC OF
(2016)
Development of single stranded DNA aptamer against Gram positive and negative bacteria using the toggle-cell SELEX.
2016 annual fall meeting of the korean biochip society.
KOREA, REPUBLIC OF
(2016)
a core-shell hybrid nanostructure based hepatic disease therapeutics using tripodal interfering RNA (tiRNA).
12th annual meeting of the oligonucleotide therapeutics society.
CANADA
